Editors' ChoiceSynaptic Plasticity

The Substrate for Protein Kinase C in LTD

STKE  17 Jun 2003:
Vol. 2003, Issue 187, pp. tw233-TW233
DOI: 10.1126/stke.2003.187.tw233

Cerebellar long-term depression (LTD) requires protein kinase C (PKC)-regulated interactions between glutamate receptor subunit GluR2 and other postsynaptic proteins. Chung et al. found that LTD could not be elicited in cultured Purkinje cells from mice that were deficient in GluR2. LTD in cells from these mice could be rescued with GluR2, but not by mutant GluR2 lacking its PKC phosphorylation site.

H. J. Chung, J. P. Steinberg, R. L. Huganir, D. J. Linden, Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300, 1751-1755 (2003). [Abstract] [Full Text]