Ubiquitination, Protein Turnover, and Long-Term Synaptic Plasticity

Sci. STKE, 8 July 2003
Vol. 2003, Issue 190, p. pe26
DOI: 10.1126/stke.2003.190.pe26

Ubiquitination, Protein Turnover, and Long-Term Synaptic Plasticity

  1. James H. Schwartz*
  1. Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
  1. *Contact information. E-mail, jhs6{at}columbia.edu

Abstract

For at least half a century, alteration of synaptic strength through growth at specific nerve terminals has been favored as the mechanism underlying long-term changes in behavior and synaptic plasticity. Although new proteins for synapses can either be synthesized locally or transported from the cell body, recent work on the postsynaptic element (dendritic spines) of cortical excitatory synapses indicates that transmission can also be modified by controlling the density of α-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid receptors (AMPARs) in the postsynaptic density (PSD). This regulation is mediated by mono-ubiquitination, which governs turnover of AMPAR subunits by determining whether the endocytosed subunits are sent to lysosomes to be degraded or recycled back to the membrane by exocytosis. Also important is activity-dependent multi-ubiquitination and degradation of proteins that make up the scaffolding complexes that confine receptors to the PSD.

Citation:

J. H. Schwartz, Ubiquitination, Protein Turnover, and Long-Term Synaptic Plasticity. Sci. STKE 2003, pe26 (2003).

Analysis of proteome dynamics in the mouse brain
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Proc. Natl. Acad. Sci. USA 107, 14508-14513 (10 August 2010)

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