Too Much, Too Soon

Science's STKE  15 Jul 2003:
Vol. 2003, Issue 191, pp. tw277-TW277
DOI: 10.1126/stke.2003.191.tw277

In female mammals, the initiation of ovarian follicular growth is somehow regulated to ensure that mature follicles are produced at each cycle. Castrillon et al. now show that female mice deficient in the Forkhead transcription factor Foxo3a displayed an age-related loss of fertility that was caused by extensive activation of ovarian follicles prior to sexual maturity. These results raise the possibility that accelerated follicular initiation contributes to premature ovarian failure, a common cause of infertility in women.

D. H. Castrillon, L. Miao, R. Kollipara, J. W. Horner, R. A. DePinho, Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301, 215-218 (2003). [Abstract] [Full Text]