Perspective

A Kelch β Propeller Featuring as a Gβ Structural Mimic: Reinventing the Wheel?

Science's STKE  15 Jul 2003:
Vol. 2003, Issue 191, pp. pe27
DOI: 10.1126/stke.2003.191.pe27

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Abstract

New genetic and protein interaction data suggest that G protein α subunits may have partners with primary sequences that are quite divergent. How this is achieved may be through the adoption of similar structures, the β propeller, by both proteins containing WD-40 repeats and kelch domains. Gettemans et al. describe results in yeast that suggest that kelch-domain proteins may serve as previously unrecognized β subunits in the heterotrimeric G protein complex.

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