Perspective

Running Interference for Hedgehog Signaling

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Science's STKE  22 Jul 2003:
Vol. 2003, Issue 192, pp. pe30
DOI: 10.1126/stke.2003.192.pe30

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Abstract

The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques.

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