Editors' ChoiceDevelopment

Prunin' and Reelin

Science's STKE  05 Aug 2003:
Vol. 2003, Issue 194, pp. tw305-TW305
DOI: 10.1126/stke.2003.194.tw305

Reelin plays a significant role during cortical development, but it continues to be expressed after its critical function in directing development of the brain's architecture is over. Quattrocchi et al. now analyze what other processes may involve reelin. Reelin is expressed in mouse neuromuscular junctions in both motor axons and muscle fibers. During development, the initially exuberant innervations of muscle fibers are normally pruned to minimize multiple innervations. In mice lacking reelin, this pruning process is deficient. Reelin function at the neuromuscular junction seems to be through its endogenous protease function, rather than through the Disabled1 signaling pathway that mediates its role in brain development.

C. C. Quattrocchi, C. Huang, S. Niu, M. Sheldon, D. Benhayon, J. Cartwright Jr., D. R. Mosier, F. Keller, G. D'Arcangelo, Reelin promotes peripheral synapse elimination and maturation. Science 301, 649-653 (2003). [Abstract] [Full Text]