Connections Map Overview

The FasL-Fas Signaling Network

Science's STKE  05 Aug 2003:
Vol. 2003, Issue 194, pp. cm5
DOI: 10.1126/stke.2003.194.cm5


Fas ligand (FasL; also known as APO-1L or CD95L) belongs to the tumor necrosis factor (TNF) ligand family, and its corresponding receptor, Fas (also known as APO-1 or CD95), is a typical member of the death receptor subgroup of the TNF receptor superfamily. Both molecules were originally identified through their apoptosis-inducing capabilities. In recent years, however, roles for Fas and FasL in nonapoptotic processes have become apparent. Fas and FasL have been implicated in such diverse processes as activation-induced cell death (AICD) in T cells, cytotoxic T cell (CTL) function, immune privilege, tumor surveillance, T cell proliferation, dendritic cell differentiation, cardiac hypertrophy, and neurite growth. Many fundamental aspects of the extrinsic apoptotic pathway, including the identification of the death domain, the definition of the death-inducing signaling complex (DISC), the cell type-specific dependency of death receptor induced apoptosis from a mitochondrial amplification loop, and the mechanisms of procaspase activation, were initially identified in the context of Fas-FasL-related studies; thus, this system is a paradigm for apoptotic death receptor signaling. The canonical Fas signaling pathway depicted in the Connections Map provides a comprehensive overview of the molecules and their relations that contribute to the complex signaling network triggered by Fas-FasL interaction.

Science Viewpoint

H. Wajant, The Fas signaling pathway: More than a paradigm. Science 296, 1635-1636 (2002). [Abstract] [Full Text]