Plant biology

Overcoming Negatives in Auxin Regulation

Science's STKE  26 Aug 2003:
Vol. 2003, Issue 197, pp. tw336-TW336
DOI: 10.1126/stke.2003.197.tw336

The plant hormone auxin is a key regulator of growth and development. Zhao et al. identified a compound, sirtinol, that stimulates biological responses similar to those initiated by auxin. They then screened for mutants of Arabidopsis that did not respond to sirtinol and identified a mutant they called sir1 that encodes a protein with similarity to a ubiquitin-activating E1-like protein. This result may help explain how auxin can rapidly degrade negative regulators as part of its mechanism of action.

Y. Zhao, X. Dai, H. E. Blackwell, S. L. Schreiber, J. Chory, SIR1, an upstream component in auxin signaling identified by chemical genetics. Science 301, 1107-1110 (2003). [Abstract] [Full Text]