Connections Map Overview

The STAT3 Pathway

Science's STKE  26 Aug 2003:
Vol. 2003, Issue 197, pp. cm13
DOI: 10.1126/stke.2003.197.cm13


Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune regulatory and homeostatic functions. STAT3 is also found in its activated state in a large number of human cancers and has been correlated with oncogenic activity and tumor maintenance in several systems. The Connections Map highlights activation of STAT3 by interleukin 6 and shows that STAT3 serves as an integration point for components in multiple signaling pathways in addition to those involving JAKs, for example, the small guanosine triphosphatase Ras, heterotrimeric guanine nucleotide-binding protein (G proteins) of the Gi/o family, and the nonreceptor tyrosine kinases of the Src family.

Science Viewpoint

D. S. Aaronson, C. M. Horvath, A road map for those who don't know JAK-STAT. Science 296, 1653-1655 (2002). [Abstract] [Full Text]