Does Selection Mold Molecular Networks?

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Science's STKE  30 Sep 2003:
Vol. 2003, Issue 202, pp. pe41
DOI: 10.1126/stke.2003.202.pe41

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The dissection of molecular networks vital to cellular life can provide important hints about optimal network design principles. However, these hints can become conclusive only if one can determine that natural selection has molded a network's structure. I illustrate the importance of thorough studies of network evolution with two recent examples, one from genome-scale networks, the other from small transcriptional regulation circuits.

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