Editors' ChoiceDevelopment

A Very Early Role for Ecdysone

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Science's STKE  30 Sep 2003:
Vol. 2003, Issue 202, pp. tw382-TW382
DOI: 10.1126/stke.2003.202.tw382

During the Drosophila life cycle, the steroid hormone ecdysone regulates cell shape changes and movements associated with metamorphosis. Kozlova and Thummel report that this hormone also acts at an earlier time point of the life cycle to establish the body plan of the early larva. This earlier pulse of hormone appears to arise from the amnioserosa, the presumed equivalent of the vertebrate placenta, which suggests a parallel between the two tissues as a critical source of hormone during development.

T. Kozlova, C. S. Thummel, Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science 301, 1911-1914 (2003). [Abstract] [Full Text]

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