Cell Biology

The Last Step Toward Integrin Activation

Science's STKE  07 Oct 2003:
Vol. 2003, Issue 203, pp. tw395-TW395
DOI: 10.1126/stke.2003.203.tw395

Integrin affinity for components of the extracellular matrix controls its activation. Integrin activation in turn is associated with numerous cell adhesion and migration events. Although many intracellular signaling pathways have been implicated in controlling the integrin-extracellular matrix interaction, the final step that results in the conformational change needed to kick integrins into activation mode has not been clear. Tadokoro et al. show that for several different classes of integrins and signaling pathways, the association of a cytoskeletal protein called talin is the final common step for integrin activation.

S. Tadokoro, S. J. Shattil, K. Eto, V. Tai, R. C. Liddington, J. M. de Pereda, M. H. Ginsberg, D. A. Calderwood, Talin binding to integrin β tails: A final common step in integrin activation. Science 302, 103-106 (2003). [Abstract] [Full Text]