Cell Cycle

Keeping in Time

Science's STKE  14 Oct 2003:
Vol. 2003, Issue 204, pp. tw402-TW402
DOI: 10.1126/stke.2003.204.tw402

A functional pathway that connects the cell cycle and the circadian clock has long been suspected. Matsuo et al. (see the Perspective by Schibler) have now identified a molecular link between these two major control systems that could explain how proliferating cells use information from the circadian clock to regulate the timing of cell division. In murine regenerating liver, the expression of three key regulators of mitosis was controlled in a diurnal fashion. One of these factors, called WEE1, was directly regulated by two transcription factors that are core components of the mammalian circadian clock.

T. Matsuo, S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, H. Okamura, Control mechanism of the circadian clock for timing of cell division in vivo. Science 302, 255 (2003). [Abstract] [Full Text]

U. Schibler, Liver regeneration clocks on. Science 302, 234 (2003). [Summary] [Full Text]