PDE4: Arrested at the Border

Sci. STKE, 14 October 2003
Vol. 2003, Issue 204, p. pe44
DOI: 10.1126/stke.2003.204.pe44

PDE4: Arrested at the Border

  1. Laurence L. Brunton*
  1. Department of Pharmacology 0636, University of California San Diego Medical School, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA.
  1. *Contact information. E-mail, lbrunton{at}ucsd.edu


Compartmentation plays a critical role in determining the specificity and efficacy of signaling by adenosine 3′,5′-monophosphate (cAMP) and other second messengers. It has become apparent that all of the protein components of the cAMP signaling pathway are subject to regulation and may be localized to particular subcellular compartments. This Perspective discusses recent research concerning the importance of cAMP phosphodiesterase localization in cAMP signaling, functional implications of the organization of this pathway's protein components into macromolecular complexes, and common themes in the compartmentation of cAMP- and Ca2+-mediated signaling pathways.


L. L. Brunton, PDE4: Arrested at the Border. Sci. STKE 2003, pe44 (2003).

PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
A. Terrin, G. Di Benedetto, V. Pertegato, Y.-F. Cheung, G. Baillie, M. J. Lynch, N. Elvassore, A. Prinz, F. W. Herberg, M. D. Houslay et al.
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