Editors' ChoiceImaging

Glycine Receptors On the Move

Science's STKE  21 Oct 2003:
Vol. 2003, Issue 205, pp. tw416-TW416
DOI: 10.1126/stke.2003.205.tw416

Semiconductor quantum dots (QDs) have recently emerged as probes with the potential to revolutionize fluorescence imaging. Dahan et al. have now detected single QD-tagged glycine receptors in living cultured spinal neurons. By combining in vivo monitoring and post hoc electron microscopic analysis, the dynamics of receptors was monitored over time and the entry of a receptor into the synapse was directly observed.

M. Dahan, S. Lévi, C. Luccardini, P. Rostaing, B. Riveau, A. Triller, Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302, 442-445 (2003). [Abstract] [Full Text]