Destroyed in Transit

Science's STKE  28 Oct 2003:
Vol. 2003, Issue 206, pp. tw424
DOI: 10.1126/stke.2003.206.tw424

Despite the huge global rise in tuberculosis, protective immunity to the causative pathogen, Mycobacterium tuberculosis (Mtb), is measurable in most infected individuals. Critical in mediating this is the cytokine interferon-γ, which activates various immune-response genes, of which nitric oxide synthase 2 (NOS2) is considered pivotal. MacMicking et al. identified a protein, LRG-47, that can mediate protection from Mtb infection independently of NOS2. Macrophages from mice lacking LRG-47 produced bacteria-laden phagosomes that could not fuse with lysosomes and thus impeded the normal cellular pathway for destroying intracellular bacteria.

J. D. MacMicking, G. A. Taylor, J. D. McKinney, Immune control of tuberculosis by IFN-γ-inducible LRG-47. Science 302, 654-659 (2003). [Abstract] [Full Text]