Ozone and Atherosclerosis

Science's STKE  11 Nov 2003:
Vol. 2003, Issue 208, pp. tw441
DOI: 10.1126/stke.2003.208.tw441

Atherosclerosis is now recognized as encompassing a complex inflammatory etiology, in which mediators of atherosclerotic plaque formation are induced by products of oxidized cholesterol. Wentworth et al. identify novel oxidized sterol species from atherosclerotic plaque tissue and provide evidence that these are formed by ozone-mediated oxidation of cholesterol. The two oxysterols displayed activity consistent with a pathogenic role in vivo and were present in sera of patients with severe atherosclerosis. Ozone production was detected in plaque tissue after exposure to mitogen, which suggests a direct link between immune activation and the generation of the novel oxidant and its products.

P. Wentworth Jr., J. Nieva, C. Takeuchi, R. Galve, A. D. Wentworth, R. B. Dilley, G. A. DeLaria, A. Saven, B. M. Babior, K. D. Janda, A. Eschenmoser, R. A. Lerner, Evidence for ozone formation in human atherosclerotic arteries. Science 302, 1053-1056 (2003). [Abstract] [Full Text]