Editors' ChoiceBRAIN DISEASE

ROCK and Rho Beat Beta Amyloid

Science's STKE  18 Nov 2003:
Vol. 2003, Issue 209, pp. tw450-TW450
DOI: 10.1126/stke.2092003TW450

Some nonsteroidal anti-inflammatory drugs have been shown to reduce the secretion of the β-amyloid peptide. Zhou et al. show that this effect may be due to their interaction with the small guanosine triphosphatase Rho and its effector kinase ROCK. Directly inhibiting ROCK led to reductions in the levels of β-amyloid peptide observed in the brains of Alzheimer's disease model mice. Thus, Rho and ROCK may be important players in Alzheimer's pathogenesis and may represent targets for therapeutic intervention.

Y. Zhou, Y. Su, B. Li, F. Liu, J. W. Ryder, X. Wu, P. A. Gonzalez-DeWhitt, V. Gelfanova, J. E. Hale, P. C. May, S. M. Paul, B. Ni, Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Aβ42 by inhibiting Rho. Science 302, 1215-1217 (2003). [Abstract] [Full Text]