Molecular Scaffolds

Nutrient Sensing and Gene Expression

Science's STKE  18 Nov 2003:
Vol. 2003, Issue 209, pp. tw451-TW451
DOI: 10.1126/stke.2092003TW451

Prefoldins belong to a family of small-molecular-weight proteins that act as molecular chaperones. Gstaiger et al. describe an unusually large member of this family, URI, that forms a large (>1 megadalton) complex with other small-molecular-weight prefoldins and a subunit shared by all three RNA polymerases. In yeast and human cells, URI is a target of nutrient signaling and participates in the control of nutrient-sensitive gene expression. Thus, URI may act as a molecular scaffold for a signaling pathway that coordinates nutrient availability with gene expression.

M. Gstaiger, B. Luke, D. Hess, E. J. Oakeley, C. Wirbelauer, M. Blondel, M. Vigneron, M. Peter, W. Krek, Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302, 1208-1212 (2003). [Abstract] [Full Text]