Editors' ChoicePhagocytosis

Molecular Dinner Invitations

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Science's STKE  02 Dec 2003:
Vol. 2003, Issue 211, pp. tw467
DOI: 10.1126/stke.2112003tw467

Apoptotic cells undergoing programmed cell death are potentially harmful, and normally, they are removed by phagocytes that engulf the dying cells. The phagocytes are thought to recognize the apoptotic cells by the presence of phosphatidylserine in the outer leaflet of the plasma membrane. Two reports show that animals lacking phosphatidylserine receptors have defects in the engulfment of cell corpses (see the Perspective by Savill et al.). Wang et al. show that in the nematode worm, Caenorhabditis elegans, the phosphatidylserine receptor appears to interact with one of two known signaling pathways that lead to the removal of cell corpses during development. Li et al. show that mice lacking the receptor have defects in development of the lung and brain caused by accumulated dead cells.

J. Savill, C. Gregory, C. Haslett, Eat me or die. Science 302, 1516-1517 (2003). [Abstract] [Full Text]

X. Wang, Y.-C. Wu, V. A. Fadok, M.-C. Lee, K. Gengyo-Ando, L.-C. Cheng, D. Ledwich, P.-K. Hsu, J.-Y. Chen, B.-K. Chou, P. Henson, S. Mitani, D. Xue, Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 302, 1563-1566 (2003). [Abstract] [Full Text]

M. O. Li, M. R. Sarkisian, W. Z. Mehal, P. Rakic, R. A. Flavell, Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 302, 1560-1563 (2003). [Abstract] [Full Text]