Editors' ChoiceDevelopment

Reactive Oxygen Species in Development and Aging

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Science's STKE  09 Dec 2003:
Vol. 2003, Issue 212, pp. tw481-TW481
DOI: 10.1126/stke.2122003TW481

As human society gets older, there is great interest in understanding the molecular mechanisms of aging. One agent that has been linked to aging is reactive oxygen species (ROSs). Shibata et al. now show that ROSs also function in the normal development of the nematode, Caenorhabditis elegans. A specific role was observed both in germline development that involved lipoprotein oxidation and in vulval development that involved activation of the small guanosine triphosphatase protein, Ras. This in vivo model will be useful in studies of ROS signaling, and it provides a system to explore the biology of lipoproteins that are important in the development of atherosclerosis.

Y. Shibata, R. Branicky, I. O. Landaverde, S. Hekimi, Redox regulation of germline and vulval development in Caenorhabditis elegans. Science 302, 1779-1782 (2003). [Abstract] [Full Text]

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