Review

TOR Signaling

Science's STKE  09 Dec 2003:
Vol. 2003, Issue 212, pp. re15
DOI: 10.1126/stke.2122003re15

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Gloss

With six figures and 221 citations, this STKE Review discusses the history and recently discovered interacting partners and effectors of TOR, a protein at the center of the regulatory and signaling pathways that control cell growth and proliferation. TOR stands for "target of rapamycin," which is a potent antifungal agent that inhibits TOR activity in many species, including yeast and humans. In simple organisms, nutrient availability appears to be the major factor influencing TOR activity. In metazoans, TOR integrates signals arising from the amino acid supply, cellular energy state, and hormone and growth factor receptors.

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