Membrane Recognition and Targeting by Lipid-Binding Domains

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Science's STKE  16 Dec 2003:
Vol. 2003, Issue 213, pp. re16
DOI: 10.1126/stke.2132003re16

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Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.

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