Membrane Recognition and Targeting by Lipid-Binding Domains

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Science's STKE  16 Dec 2003:
Vol. 2003, Issue 213, pp. re16
DOI: 10.1126/stke.2132003re16

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With eight figures, one table, and 155 references, this STKE Review describes the structural features that explain how modular domains interact with lipids. Various specific and nonspecific interactions contribute to the ability of proteins to recognize cellular membranes, allowing proteins with lipid-binding domains to play roles in cellular signaling and membrane trafficking.