EH and UIM: Endocytosis and More

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Science's STKE  16 Dec 2003:
Vol. 2003, Issue 213, pp. re17
DOI: 10.1126/stke.2132003re17

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This STKE Review, with 4 figures, 7 tables, and 181 references, concerns protein interaction networks built through two classes of protein-protein interactions, those involving the Eps15 homology (EH) domain and those that depend on monoubiquitination, a posttranslational modification that creates the monoubiquitin (mUb)-network. Functional and physical protein networks linked by protein interaction domains--regions with conserved structure and amino acid sequence--can be created through signaling events and serve functions critical to intracellular signaling pathways. The protein networks involving EH domains and ubiquitin (Ub)-interacting motifs (UIMs) were initially implicated in the regulation of receptor endocytosis and in the trafficking of intracellular vesicles. More recent data, however, indicate that both networks serve other important functions as well. This review integrates available knowledge on the EH- and mUb networks with predictions based on functional genomics.