Generating Tubes During Development

Science's STKE  06 Jan 2004:
Vol. 2004, Issue 214, pp. tw10
DOI: 10.1126/stke.2142004tw10

In the animal world, the development of several organs involves tube formation, for example, the development of kidney, lung, and blood vessels. Berry et al. (see the Perspective by Paul and Beitel) examined genes required for proper tube formation and/or maintenance in the excretory system of the nematode, Caenorhabditis elegans. They identified and characterized a putative intracellular chloride channel that functions early in tube morphogenesis, at about the time the lumen begins to form. Mutations in this gene lead to the formation of cysts rather than a continuous luminal channel in the developing excretory system.

K. L. Berry, H. E. Bülow, D. H. Hall, O. Hobert, A C. elegans CLIC-like protein required for intracellular tube formation and maintenance. Science 302, 2134-2137 (2003). [Abstract] [Full Text]

S. M. Paul, G. J. Beitel, Tubulogenesis CLICs into place. Science 302, 2077-2078 (2003). [Abstract] [Full Text]