Stem Cells

Hiding Out in Hair Follicles

Science's STKE  20 Jan 2004:
Vol. 2004, Issue 216, pp. tw28-TW28
DOI: 10.1126/stke.2162004TW28

Stem cells for mammalian skin are thought to reside in the hair follicles, where a stem cell niche harbors its residents until the time comes to initiate new hair growth or to regenerate skin. Tumbar et al. develop a strategy to highlight the slowly dividing skin cells likely to represent such epithelial stem cells. Further analysis into the transcriptional profile of these cells reveals suites of proteins dedicated to reading the environment in preparation for stem cell activation.

T. Tumbar, G. Guasch, V. Greco, C. Blanpain, W. E. Lowry, M. Rendl, E. Fuchs, Defining the epithelial stem cell niche in skin. Science 303, 359-363 (2004). [Abstract] [Full Text]