Editors' ChoiceProteomics

Interactions Within Worms

Science's STKE  27 Jan 2004:
Vol. 2004, Issue 217, pp. tw36-TW36
DOI: 10.1126/stke.2172004TW36

Interaction maps for the whole proteome of an organism will lend insight into multiple metabolic pathways. The generation of such a map for a simple metazoan should provide a model for generating such a map for humans. Li et al. describe more than 5000 protein-protein interactions in the nematode worm, Caenorhabditis elegans. Analysis of interactions that have been conserved from unicellular yeast to the multicellular nematode revealed that evolutionarily recent proteins and ancient proteins do not segregate into distinct interaction clusters. Thus, evolution of new cellular functions has proceeded by combining novel elements with those from preexisting architectures.

S. Li, C. M. Armstrong, N. Bertin, H. Ge, S. Milstein, M. Boxem, P.-O. Vidalain, J.-D. J. Han, A. Chesneau, T. Hao, D. S. Goldberg, N. Li, M. Martinez, J.-F. Rual, P. Lamesch, L. Xu, M. Tewari, S. L. Wong, L. V. Zhang, G. F. Berriz, L. Jacotot, P. Vaglio, J. Reboul, T. Hirozane-Kishikawa, Q. Li, H. W. Gabel, A. Elewa, B. Baumgartner, D. J. Rose, H. Yu, S. Bosak, R. Sequerra, A. Fraser, S. E. Mango, W. M. Saxton, S. Strome, S. van den Heuvel, F. Piano, J. Vandenhaute, C. Sardet, M. Gerstein, L. Doucette-Stamm, K. C. Gunsalus, J. W. Harper, M. E. Cusick, F. P. Roth, D. E. Hill, M. Vidal, A map of the interactome network of the metazoan C. elegans. Science 303, 540-543 (2004). [Abstract] [Full Text]

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