G Protein Signaling: Insights from New Structures

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Science's STKE  03 Feb 2004:
Vol. 2004, Issue 218, pp. re3
DOI: 10.1126/stke.2182004re3

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A large body of experimental evidence exists that links heterotrimeric guanosine triphosphate–binding protein (G protein) structure to function. The determination of the crystal structures of G proteins in various activational states and, more recently, in complexes with effectors and other signaling partners highlights the varied mechanisms involved in G protein regulation. Signaling complexes, such as the recently solved complex of Gβγ and G protein receptor kinase 2 (GRK2), provide new insights into the mechanisms underlying the regulation of these highly conserved signaling molecules. In this Review, we discuss the latest findings and their implications for G protein–signaling paradigms.

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