Dopamine D2 Receptor Function Unraveled

Science's STKE  10 Feb 2004:
Vol. 2004, Issue 219, pp. tw53
DOI: 10.1126/stke.2192004TW53

Cortical dopaminergic systems are involved in normal and abnormal cognition. Dopaminergic D2 antagonists are widely used in the treatment of schizophrenia. During the performance of tasks requiring working memory, cells in the frontal cortex discharge in relation to the memory period or in relation to guided memory saccades. Wang et al. applied D2 and D1 agonists and antagonists to single neurons in the brains of awake, behaving monkeys. Dopamine D2 receptors selectively controlled the activity associated with making memory-guided saccades, whereas D1 receptors controlled the persistent activity during the memory period. Thus, D2 receptors control working-memory-related activities in the prefrontal cortex.

M. Wang, S. Vijayraghavan, P. S. Goldman-Rakic, Selective D2 receptor actions on the functional circuitry of working memory. Science 303, 853-856 (2004). [Abstract] [Full Text]