Local Excitation, Global Inhibition Mechanism for Gradient Sensing: An Interactive Applet

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Science's STKE  10 Feb 2004:
Vol. 2004, Issue 219, pp. pl3
DOI: 10.1126/stke.2192004pl3

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We have proposed a model in which cells detect gradients of chemoattractant by balancing a fast local excitation and a slower global inhibition. To illustrate this general mechanism, we have developed an interactive applet that mimics laboratory experiments in which either spatially homogeneous or heterogeneous stimuli of chemoattractant are applied.

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