Review

Mechanosensitive Channels: Multiplicity of Families and Gating Paradigms

Science Signaling  10 Feb 2004:
Vol. 2004, Issue 219, pp. re4
DOI: 10.1126/stke.2192004re4

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  1. Article
    1. Abstract
    2. Introduction
    3. The Nature of the Primary Transducer
    4. Channel Gating by External Force
    5. Cellular Structures That Convey Force to a Channel
    6. DEG/ENaC Channels
    7. TRP Channels
    8. Mechanosensitive Channel Activities in Nonsensory Cells
    9. What Happens Under the Patch Pipette?
    10. Why Do Walled Cells Have Mechanosensitive Channels?
    11. Bacterial Mechanosensitive Channels Are Osmotic Safety Valves
    12. MscL, a Simple Model
    13. Mechanosensitive Channels: Do They Have Anything in Common?
    14. Concluding Remarks
    15. Appendix: Energetics of Mechanical Gating
    16. References
  2. Figures & Data
  3. Info & Metrics
  4. eLetters
  5. PDF