Editors' ChoiceCell Biology

Managing Cellular Adhesions During Movement

Science's STKE  10 Feb 2004:
Vol. 2004, Issue 219, pp. tw57
DOI: 10.1126/stke.2192004TW57

During migration, microtubules are stabilized at the cell's leading edge. At the same time, focal adhesions form in this region and integrins at the cell surface associate with the extracellular matrix to initiate adhesion-induced signals. Palazzo et al. (see the Perspective by Guan) report that a signaling pathway that manages microtubule stability through the small guanosine triphosphate-binding protein Rho is linked to an integrin-mediated signaling pathway at the leading edge. Specific membrane microdomains at the cell surface may serve as an intermediary to facilitate pathway interaction. Similar membrane microdomains are also targeted by the Rho-related protein Rac. Del Pozo et al. (see the Perspective by Guan) found that when cells detach from extracellular matrix, such membrane microdomains and their associated Rac are internalized, which prevents downstream signaling events in the integrin-Rac pathway that controls processes, such as cell migration.

A. F. Palazzo, C. H. Eng, D. D. Schlaepfer, E. E. Marcantonio, G. G. Gundersen, Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science 303, 836-839 (2004). [Abstract] [Full Text]

J.-L. Guan, Integrins, rafts, Rac, and Rho. Science 303, 773-774 (2004). [Summary] [Full Text]

M. A. del Pozo, N. B. Alderson, W. B. Kiosses, H.-H. Chiang, R. G. W. Anderson, M. A. Schwartz, Integrins regulate Rac targeting by internalization of membrane domains. Science 303, 839-842 (2004). [Abstract] [Full Text]