Cancer Biology

Tumor Suppressor Doing Double Duty

Science's STKE  24 Feb 2004:
Vol. 2004, Issue 221, pp. tw74-TW74
DOI: 10.1126/stke.2212004TW74

The tumor suppressor protein PTEN is a dual-specificity phosphatase whose catalytic domain acts primarily on lipids but can also target proteins. Raftopoulou et al. report that PTEN lipid phosphatase activity is not required for PTEN to inhibit cell migration. Instead, its protein phosphatase activity is required to dephosphorylate a single residue in its C-terminal tail, which in turn regulates migration. This mechanism may contribute to the progression of tumors that harbor catalytically inactive forms of PTEN.

M. Raftopoulou, S. Etienne-Manneville, A. Self, S. Nicholls, A. Hall, Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303, 1179-1181 (2004). [Abstract] [Full Text]