Resistin' a Knockout

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Science's STKE  24 Feb 2004:
Vol. 2004, Issue 221, pp. tw75-TW75
DOI: 10.1126/stke.2212004TW75

Obesity is one of the most potent risk factors for insulin resistance and type 2 diabetes, but the molecular mechanisms underlying this link are poorly understood. The fat-derived hormone resistin has been postulated to be part of that mechanism, but its role in glucose homeostasis has been controversial. Banerjee et al. now show that mice lacking resistin have low fasted blood glucose levels caused by reduced glucose production in the liver. Resistin-null mice fed a high-fat diet were less prone to exhibit the elevated glucose levels seen in wild-type mice on a similar diet, which supports the idea that resistin mediates the hyperglycemia associated with obesity. These results will likely stimulate further research exploring whether resistin has a comparable role in humans.

R. R. Banerjee, S. M. Rangwala, J. S. Shapiro, A. S. Rich, B. Rhoades, Y. Qi, J. Wang, M. W. Rajala, A. Pocai, P. E. Scherer, C. M. Steppan, R. S. Ahima, S. Obici, L. Rossetti, M. A. Lazar, Regulation of fasted blood glucose by resistin. Science 303, 1195-1198 (2004). [Abstract] [Full Text]

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