Bind and Release

Science's STKE  09 Mar 2004:
Vol. 2004, Issue 223, pp. tw87-TW87
DOI: 10.1126/stke.2232004TW87

The transmembrane AMPA receptor regulatory proteins (TARPs) regulate membrane insertion and appropriate synaptic targeting of AMPA receptors. Tomita et al. examined the interaction and dissociation mechanisms of AMPA receptors with TARP proteins. Stimulation with glutamate or AMPA decreased the association of AMPA receptors with TARPs and led to AMPA receptor endocytosis without disturbing the TARPs on the neuronal surface. Thus, agonist-induced allosteric changes in AMPA receptor conformation, even without ion channel activation, may be enough to induce the dissociation of AMPA receptors from their TARPs.

S. Tomita, M. Fukata, R. A. Nicoll, D. S. Bredt, Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science 303, 1508-1511 (2004). [Abstract] [Full Text]