Accessing Natural Products by Combinatorial Biosynthesis

Science's STKE  23 Mar 2004:
Vol. 2004, Issue 225, pp. pe14
DOI: 10.1126/stke.2252004pe14

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Enhancement and selective production of the protein phosphatase IIa inhibitor phoslactomycin (PLM) B by rational engineering of the PLM biosynthetic pathway highlights the effectiveness of combinatorial biosynthesis as a promising way to prepare complex natural products and their analogs.

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