Cell Biology

Formin in Motion

Science's STKE  30 Mar 2004:
Vol. 2004, Issue 226, pp. tw120-TW120
DOI: 10.1126/stke.2262004TW120

Formins are proteins involved in the nucleation of actin and associate with the fast-growing end of actin filaments. Higashida et al. now observe the movement of formins in living cells as actin filaments grow. The movement does not require microtubules or their motors or the actin-based motor protein myosin. Instead, the forming protein appears to "surf" along with the growing actin ends. The movement was promoted by a constitutively active form of the small GTP-binding protein, Rho, which plays a role in a variety of actin-remodeling processes.

C. Higashida, T. Miyoshi, A. Fujita, F. Oceguera-Yanez, J. Monypenny, Y. Andou, S. Narumiya, N. Watanabe, Actin polymerization-driven molecular movement of mDia1 in living cells. Science 303, 2007-2010 (2004). [Abstract] [Full Text]