Recordings from Synfire Chains

Science's STKE  27 Apr 2004:
Vol. 2004, Issue 230, pp. tw155-TW155
DOI: 10.1126/stke.2302004TW155

The idea that the nervous system plays out highly specific patterns of network activity may be a key step in closing the gap between neural network models and experimental neurophysiology. Theoreticians have long proposed that cortical activity takes the form of sequences of synchronous activity, the so-called synfire chains. Ikegaya et al. (see the Perspective by Abeles) used brain slice intracellular recordings to show patterns of postsynaptic currents, optical recordings of slice, and in vivo multicellular recordings to demonstrate the existence of these chains. Blocking NMDA or dopamine D1 receptors also reduced the chains.

Y. Ikegaya, G. Aaron, R. Cossart, D. Aronov, I. Lampl, D. Ferster, R. Yuste, Synfire chains and cortical songs: Temporal modules of cortical activity. Science 304, 559-564 (2004). [Abstract] [Full Text]

M. Abeles, Time is precious. Science 304, 523-524 (2004). [Summary] [Full Text]