Metabolic Modulation of Potassium Channels

Sci. STKE, 18 May 2004
Vol. 2004, Issue 233, p. pe22
DOI: 10.1126/stke.2332004pe22

Metabolic Modulation of Potassium Channels

  1. Dirk Trauner1,* and
  2. Richard H. Kramer2
  1. 1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  2. 2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  1. *Corresponding author. E-mail: trauner{at}


Recent investigations have shown that a range of small molecules that reflect the metabolic state of a cell regulate the activity of potassium channels. For instance, hydrogen peroxide has been shown to activate adenosine 5′-triphosphate–sensitive potassium channels (KATP channels), whereas heme closes certain calcium-activated potassium channels. Although the exact function of the β subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism.


D. Trauner and R. H. Kramer, Metabolic Modulation of Potassium Channels. Sci. STKE 2004, pe22 (2004).

Oxidative modification of M-type K+ channels as a mechanism of cytoprotective neuronal silencing
N. Gamper, O. Zaika, Y. Li, P. Martin, C. C. Hernandez, M. R. Perez, A. Y. Wang, D. B. Jaffe, and M. S. Shapiro
EMBO J. 25, 4996-5004 (18 October 2006)

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