CD40: A Growing Cytoplasmic Tale

Sci. STKE, 15 June 2004
Vol. 2004, Issue 237, p. pe25
DOI: 10.1126/stke.2372004pe25

CD40: A Growing Cytoplasmic Tale

  1. Margaret M. Harnett
  1. Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK.
  1. *Corresponding author. E-mail: m.harnett{at}


CD40, a member of the tumor necrosis factor (TNF) receptor family that is expressed on B cells, monocytes, dendritic cells, endothelial cells, and epithelial cells, as well as on B cell lymphomas and carcinomas, activates multiple signaling pathways. In B cells, the response to CD40 is complex and depends on the maturation status of the cell. It is well established that CD40 can promote cell survival through up-regulation of the expression of genes encoding antiapoptotic proteins. However, a new role for CD40 signaling is being recognized in promoting progression through the cell cycle. The roles of the phosphoinositide 3-kinase, mitogen-activated protein kinase, and nuclear factor κB pathways in mediating CD40 stimulation of the cell cycle are described.


M. M. Harnett, CD40: A Growing Cytoplasmic Tale. Sci. STKE 2004, pe25 (2004).

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