Receptor signaling

Arrestin's Nemesis

Science's STKE  29 Jun 2004:
Vol. 2004, Issue 239, pp. tw233-TW233
DOI: 10.1126/stke.2392004TW233

The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin. Arrestin regulates almost all GPCR-mediated signaling and trafficking. Wang et al. now find that spinophilin, a multidomain protein that interacts with GPCRs, regulates both the signaling and trafficking of these receptors in vitro and in vivo by functionally antagonizing the multiple roles of arrestin in these processes.

Q. Wang, J. Zhao, A. E. Brady, J. Feng, P. B. Allen, R. J. Lefkowitz, P. Greengard, L. E. Limbird, Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304, 1940-1944 (2004). [Abstract] [Full Text]