Editors' ChoiceAging

Eat Less, Live Longer

STKE  20 Jul 2004:
Vol. 2004, Issue 242, pp. tw265-TW265
DOI: 10.1126/stke.2422004TW265

Health problems in the elderly are thought to result from the cumulative effects of cell loss over time. Caloric restriction and genetic manipulations that extend life-span typically reduce stress-induced apoptotic cell death. In yeast, caloric restriction increases life-span by activating the Sir2 deacetylase. Cohen et al. now find that mammalian Sir2 (SIRT1), a regulator of cell defenses, is induced in calorically restricted rats and in human cells treated with serum from these animals. One way in which caloric restriction extends mammalian life-span may be by increasing SIRT1 expression and thus the survival of key cells.

H. Y. Cohen, C. Miller, K. J. Bitterman, N. R. Wall, B. Hekking, B. Kessler, K. T. Howitz, M. Gorospe, R. de Cabo, D. A. Sinclair, Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392 (2004) [Abstract][Full Text]