Store-Operated Calcium Channels: How Do We Measure Them, and Why Do We Care?

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Science's STKE  27 Jul 2004:
Vol. 2004, Issue 243, pp. pe37
DOI: 10.1126/stke.2432004pe37

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A major mechanism whereby calcium entry into cells is regulated is the store-operated or capacitative calcium entry pathway. In this article, two basic issues are discussed: (i) the methods investigators use to measure store-operated entry, and (ii) the role played by the store-operated pathway in responses to hormones and neurotransmitters under physiological conditions. The two topics are considered together because they are closely interrelated; as we begin to ask questions about calcium movements at low concentrations of agonists, the technology to measure these movements becomes increasing challenging.

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