Store-Operated Calcium Channels: How Do We Measure Them, and Why Do We Care?

Sci. STKE, 27 July 2004
Vol. 2004, Issue 243, p. pe37
DOI: 10.1126/stke.2432004pe37

Store-Operated Calcium Channels: How Do We Measure Them, and Why Do We Care?

  1. James W. Putney Jr.*
  1. National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Post Office Box 12233, Research Triangle Park, NC 27709, USA.
  2. Present address (until 21 August 2004): Laboratory of Physiology, Oxford University, Oxford OX1 3PT, UK.
  1. *Contact information. E-mail: putney{at}niehs.nih.gov

Abstract

A major mechanism whereby calcium entry into cells is regulated is the store-operated or capacitative calcium entry pathway. In this article, two basic issues are discussed: (i) the methods investigators use to measure store-operated entry, and (ii) the role played by the store-operated pathway in responses to hormones and neurotransmitters under physiological conditions. The two topics are considered together because they are closely interrelated; as we begin to ask questions about calcium movements at low concentrations of agonists, the technology to measure these movements becomes increasing challenging.

Citation:

J. W. Putney, Store-Operated Calcium Channels: How Do We Measure Them, and Why Do We Care?. Sci. STKE 2004, pe37 (2004).

Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals
D. L. Gill, and R. L. Patterson
Sci Signal 2004, pe39-pe39 (27 July 2004)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882