Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals

See allHide authors and affiliations

Science's STKE  27 Jul 2004:
Vol. 2004, Issue 243, pp. pe39
DOI: 10.1126/stke.2432004pe39

You are currently viewing the abstract.

View Full Text


Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.

View Full Text