Cell Cycle

Getting Out of Mitosis

Science's STKE  27 Jul 2004:
Vol. 2004, Issue 243, pp. tw274
DOI: 10.1126/stke.2432004tw274

The protein phosphatase Cdc14 controls a number of the late events of mitosis. Cdc14 is sequestered in the nucleolus, but late in mitosis, it is released and moves throughout the cell to help to coordinate the exit from mitosis. Cdc14 is held in the nucleus through interaction with a protein called Net1. Azzam et al. show that release of Cdc14 appears to depend on phosphorylation of Net1 by the master regulator of mitosis, the complex of cyclin B and cyclin-dependent kinase.

R. Azzam, S. L. Chen, W. Shou, A. S. Mah, G. Alexandru, K. Nasmyth, R. S. Annan, S. A. Carr, R. J. Deshaies, Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 305, 516-519 (2004). [Abstract] [Full Text]