Cell Migration

Repulsive Signaling

Science's STKE  10 Aug 2004:
Vol. 2004, Issue 245, pp. tw289
DOI: 10.1126/stke.2452004tw289

Plexins are cell surface receptors for the semaphorin family of guidance molecules. Semaphorins were originally identified as repulsive axonal guidance molecules in the developing nervous system, but they are also implicated in morphogenesis, angiogenesis, immune response, and tumor metastasis in a variety of tissues. Oinuma et al. describe a signal transduction pathway mediated by a semaphorin, the transmembrane receptor Plexin-B1. Plexin-B1 acts as a guanosine triphosphatase (GTPase)-activating protein toward the Ras family small GTPase R-Ras, a key regulator of cell adhesion, to promote repulsive signaling by Plexin-B1.

I. Oinuma, Y. Ishikawa, H. Katoh, M. Negishi, The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science 305, 862-865 (2004). [Abstract] [Full Text]