Dapper2 and Making Mesoderm

Science's STKE  05 Oct 2004:
Vol. 2004, Issue 253, pp. tw359
DOI: 10.1126/stke.2532004tw359

Members of the transforming growth factor-β (TGF-β) superfamily, such as Nodal, act as inducers for the formation of vertebrate mesoderm. In particular, Nodal is needed for normal embryo development, and its signaling must be tightly controlled. Zhang et al. report that Dapper2 modulates Nodal signaling activity in zebrafish embryos: Loss of Dapper2 leads to upregulation of Nodal-responsive genes in early gastrula and, conversely, overexpression of Dapper2 yields downregulation of Nodal-responsive genes. Dapper2 coprecipitates with and disrupts the interactions of components of the TGF-β signaling pathway and promotes lysosomal TGF-β receptor degradation.

L. Zhang, H. Zhou, Y. Su, Z. Sun, H. Zhang, L. Zhang, Y. Zhang, Y. Ning, Y.-G. Chen, A. Meng, Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science 306, 114-117 (2004). [Abstract] [Full Text]