Teaching Resource

AMPA Receptor Cycling in the Synapse

Science's STKE  19 Oct 2004:
Vol. 2004, Issue 255, pp. tr7
DOI: 10.1126/stke.2552004tr7

Abstract

Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and, therefore, are central to processes thought to underlie learning and memory. The animation provides an interactive illustration of how activity-dependent changes in the glutamate receptor composition and numbers at the synapse may contribute to synaptic plasticity.

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